A colonoscopy is one of the most common outpatient procedures in the United States, and one of the most aggressively overbilled on hospital bills. The Medicare-set rate for CPT 45378 (diagnostic colonoscopy) is roughly $169 to $630 depending on the setting. Hospitals routinely bill anywhere from $1,500 to $8,500 for the same code.. Learn the full breakdown of colonoscopy cost with and without insurance in 2026, plus tips to save money on this essential screening procedure.

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Frequently Asked Questions How much does a colonoscopy cost without insurance? The average negotiated rate for a colonoscopy (CPT 45378) is $517 nationally. Rates typically range from $269 to $1,217 depending on your state and provider. Without insurance, you may pay the provider's full charge rate, which can be 2-3x higher than negotiated rates.. Colonoscopy costs can exceed $4,000 without insurance. What you'll pay out of pocket depends on whether you have insurance, where the procedure is performed, and other factors.